秦静

文章来源: 发布时间:2023-07-04浏览次数:

姓名:秦静

硕士生导师

职称:副教授

联系方式:

qinjing@sdfmu.edu.cn

研究方向:

1. 抗肿瘤及抗菌金属配合物设计、合成及相关机制研究

2. 新污染物对药物药效影响机制研究

主持科研课题:

1. 国家自然科学基金青年项目,22306112微塑料与典型抗癌药物界面行为及其对药效影响机制研究,2023/01-2026/1230万元,在研,主持

2. 山东省自然科学基金青年项目,ZR2023QH347新型芳香化酶抑制/雌激素受体调节双重功效抗乳腺癌药物分子设计、合成及活性研究,2023/01-2026/1215万元,在研,主持

3. 永利yl23411官网高层次人才资助项目,2022/07-2027/07200万元,在研,主持

近五年代表性论文(限第一作者和通讯作者):

1. Han, B., Ji, Y., Qin, J*., Liu, L*., & Wang, G*, Manganese-catalyzed aerobic cross-dehydrogenative coupling of thiols with P (O) H compounds, Tetrahedron Letters, 2025, 155566.

2. Qin, J., Xia, P. F., Yuan, X. Z., Wang, S. G*, Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis. Journal of hazardous materials, 2022; 425: 127842.

3. Qin, J., Sun, X., Ma, Y., Cheng, Y., Ma, Q., Liu, L*, Design, synthesis and biological evaluation of novel 1, 3, 4, 9-tetrahydropyrano [3, 4-b] indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway, Bioorganic & Medicinal Chemistry, 2022; 55:116594.

4. Qin, J., Qu, S., Zhu, K., Cheng, Y., Pan, G., Liu, L*, Rational design and synthesis of 6-aryl-6H-benzo [c] chromenes as non-steroidal progesterone receptor antagonists for use against cancers, Bioorganic & Medicinal Chemistry, 2021; 32: 116003.



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