
姓名:卢志远
硕士生导师,博士后合作导师
职称:副教授,泰山学者青年专家,山东高校青创团队负责人
联系方式:luzhiyuan@sdfmu.edu.cn
研究方向:
1. 炎症免疫、血液和神经退行性等疾病中药活性成分发现
2. 天然先导药物分子靶点鉴定以及药理机制研究
3. 中药纳米活性物质发现及中药现代化
主要学术任职:
1. 中国药理学会生化与分子药理学专业委员会青年委员
2. 山东省研究型医院协会杰出青年学者分会常务委员
3. 中国民族医药学会方药量效研究分会理事
4. 中国中医药研究促进会免疫疾病分会委员
5. 山东中医药学会中医基础理论专业委员会委员
6. Journal of Ginseng Research杂志副主编
7. Chinese Medicine、iMed、Acta Materia Medica、Traditional Medicine Research、Science of Traditional Chinese Medicine、Pharmaceutical Science Advances、Med Research、Pharmacology Discovery和《中医药研究进展 》等杂志编委或青年编委
主要获奖情况(包括作为指导教师):
1. 2025年,山东省中药协会青年人才奖
主持科研课题:
1. 山东省泰山学者青年专家,2025.01-2027.12,75万,在研。
2. 国家自然科学基金青年项目,32300957,磷酸酶PPM1B调控巨噬细胞M1型极化介导溃疡性结肠炎发展的分子机制研究,30万,2024.01-2026.12,在研。
3. 山东省自然科学基金青年项目,ZR2023QH427,基于蛋白磷酸酶PPM1B的急性B淋巴细胞白血病治疗新靶标的发现, 2024.01-2026.12,15万,在研。
4. 山东省高等学校 “ 青创团队计划 ”, 2022KJ197, 参麦注射液抗新冠肺炎危重症感染的活性成分及分子机制研究,2023.01-2025.12,30 万,在研。
5. 山东省医药卫生科技发展计划项目-青年项目,Q-2023107,党参碳量子点的制备、表征及在贫血治疗中的应用,2023.08-2025.07,2 万,在研。
6. 广东省重点实验室开放课题,5万,2024.01-2025.12,在研
7. 永利yl23411官网高层次人才引进经费资助项目,2022.07-2027.06,200万,在研。
近五年代表性论文(限第一作者和通讯作者):
1. Zhiyuan Lu#, Lixia Huang#, Yanxia Li, et al. Fine-tuning of cholesterol homeostasis controls erythroid differentiation. Advanced Science. 2021,2102669:1-17. (1区, IF: 17.52)
2. Zhiyuan Lu, Hanzhi Yu, Yanxia Li, et al. Phosphatase, Mg2+/Mn2+ Dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/-catenin signaling. Haematologica.2023, 109( 7) : 2144-2156. (1区, IF: 10.1)
3. Xiang Li#, Yanjiao Ding#, Jingwen Xue#, Yinxue Fu, Fang Yan, Nannan Song, Honggang Hu, Wei Cong*, Zhiyuan Lu*, Yulei Li*. Peptide Double-Stapling and Arginine N-Glycosylation Triggered the Development of Therapeutic Antimicrobial Peptides Capable of Killing Drug-Resistant Bacteria in Mice. Journal of Medicinal Chemistry. 2025, 68(4): 4511-4526. (1区, IF: 6.8)
4. Zhiyuan Lu*, Haojia Li, Nannan Song, Zhiwei Wang, Hua Wang, Asma Rehman, Liwen Han, Ke-Wu Zeng*. Therapeutic Potential of Carbon Dots Derived from Phytochemicals as Nanozymes Exhibiting Superoxide Dismutase Activity for Anemia. ACS Appl Mater Interfaces. 2025;17(3):4562-4578. (2区, IF: 8.6)
5. Zhiyuan Lu#, Guangsen Xu#, Yanxia Li#, et al. Discovery of N-arylcinnamamides as Novel Erythroblast Enucleation Inducers. Bioorganic Chemistry. 2022, 128:106105. (1区, IF: 5.30)
6. Lei Wang#, Zhong-Yao Li#, Chong-Lei Zhong#, Zi-Yang Teng, Bin Wang, Asma Rehman, Li-Wen Han, Ke-Wu Zeng*, Ji-Guo Zhang*, Zhi-Yuan Lu*. Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury. Chinese medicine. 2025, 20(1):49. (2区, IF: 5.30)
7. Zhiyuan Lu, Peng Xiao, Yuan Zhou, et al. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. Journal of Cellular and Molecular Medicine. 2020, 00: 1-9. (2区, IF: 5.32)
8. Zhongyao Li, Ruoyu Chen, ……, Kewu Zeng*, Zhiyuan Lu*. A comprehensive overview of PPM1B: From biological functions to diseases. European Journal of Pharmacology. 2023, 947: 175633. (2区, IF: 5.19)
9. Shuai Wang#, Zhiyuan Lu#, Yuxin Wang, et al. Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats. Nutrition & Metabolism. 2020, 17: 66. (2区, IF: 4.72)